Overcoming Resistance to Bromodomain Inhibition in Myc-Driven Lymphoma

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

SJ Hogg, SJ Vervoort, S Deswal, CJ Ott, J Li, LA Cluse, PA Beavis, PK Darcy, BP Martin, A Spencer, AK Traunbauer, I Sadovnik, K Bauer, P Valent, JE Bradner, J Zuber, J Shortt, RW Johnstone

2017-02-28

BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that..